[1]沈萍,覃宇.4-氨基-1-萘甲腈的合成路线改进与结构表征[J].武汉职业技术学院学报,2012,(03):95-98.
　SHEN Ping,QIN Yu.Research on Improving Synthetic Route and Structural Characterization of 4 - amino -1- naphthalene Carbonitrile[J].Journal of Wuhan Polytechnic,2012,(03):95-98.
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4-氨基-1-萘甲腈的合成路线改进与结构表征()
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《武汉职业技术学院学报》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2012年03期
页码:
95-98
栏目:
出版日期:
2012-05-01

文章信息/Info

Title:
Research on Improving Synthetic Route and Structural Characterization of 4 - amino -1- naphthalene Carbonitrile
文章编号:
1671-931X （2012） 03-0095-04
作者:
沈萍; 覃宇
武汉职业技术学院生物工程学院，湖北武汉430074
Author(s):
SHEN Ping; QIN Yu
School of Biological Engineering, Wuhan Polytechnic, Wuhan430074, China
关键词:
4-氨基-1-萘甲腈; L-脯氨酸; 氰基化反应; 催化
Keywords:
4-amino-1-naphthalenecabonitrile;  L-proline;  cyano reaction;  catalysis
分类号:
TQ246.7
文献标志码:
A
摘要:
目的改进重要的医药化工中间体4-氨基-1萘甲腈的合成路线。方法以萘胺为原料,通过氨基保护、亲核取代、氨基去保护等步骤合成了该化合物,最终产率为81.6%。结果产物结构经过元素分析、IR和1HNMR表征,证实为目标分子。结论在分子结构中引入氰基一步中,采用L-脯氨酸为催化剂,CuCN为氰基化试剂,提高了氰基化效率,降低了对环境的危害。
Abstract:
The research aims to improve the synthetic route of 4-amino-1-naphthalene carbonitrile, which is an important pharmaceutical and chemical intermediate. The naphthylamine was used as raw materials; a compound was prepared by amino protection, nucleophilic substitution, amino unprotection and other steps. The total yield was 81.6%. Results show that the structure of the product was characterized by elemental analysis, IR and 1H NMR, which con— firmed that was the target molecule. Thus, the paper concludes that in the process of introducing cyano into the molecu— lar structure, when L-proline is used as catalyst, CuCN reagent for the cyano, the efficiency can be improved signifi— cantly and the harm to the environment can be reduced.

备注/Memo

备注/Memo:
收稿日期：2011-09-24 基金项目：湖北省教育厅科学技术研究计划指导性项目渊B类冤野4-氨基-1-萘甲腈的合成路线改进与结构表征冶渊项目编号院B20016001冤遥 作者简介：沈萍渊1970-冤袁女袁湖北武汉人袁武汉职业技术学院生物工程学院副教授袁研究方向院有机化学遥
更新日期/Last Update: 2012-06-15