[1]陈洁.TNF-α与胰岛素抵抗及其姜黄素的干预作用[J].武汉职业技术学院学报,2016,(01):91-95.
　CHEN Jie.On Effect of Curcumin on Insulin Resistance and TNF-αin High Fat Diet Fed Rats[J].Journal of Wuhan Polytechnic,2016,(01):91-95.
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TNF-α与胰岛素抵抗及其姜黄素的干预作用()
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《武汉职业技术学院学报》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2016年01期
页码:
91-95
栏目:
出版日期:
2016-02-28

文章信息/Info

Title:
On Effect of Curcumin on Insulin Resistance and TNF-αin High Fat Diet Fed Rats
文章编号:
1671-931X（2016）01-0091-05
作者:
陈洁
武汉职业技术学院 生物工程学院，湖北 武汉 430074
Author(s):
CHEN Jie
School of Biology Engineering, Wuhan Polytechnic, Wuhan 430074, China
关键词:
姜黄素; 胰岛素抵抗; 2型糖尿病; TNF-α; 游离脂肪酸
Keywords:
curcumin;  insulin resistance;  type 2 diabetes mellitus;  TNF-α;  free fatty acid (FFA)
分类号:
R587.1
文献标志码:
A
摘要:
采用高脂饲料喂养雄性SD大鼠60天，诱导IR及T2DM，并将之随机分为模型组、姜黄素组（80 mg/kg/day）、罗格列酮组（1 mg/kg/day）和两药联用组，在高脂饲料喂养同时给予以上药物。经60天给药后，分别测定各实验组空腹血糖、血浆胰岛素、总胆固醇、高密度脂蛋白、甘油三酯、低密度脂蛋白及游离脂肪酸；稳态模式评估法测定胰岛素抵抗指数；放射免疫法测定TNF-α。结果显示姜黄素能降低高脂饲养大鼠的血糖和提高其胰岛素敏感性，其机制至少部分是由姜黄素显著降低TNF-α水平的抗炎特性及降低血浆游离脂肪酸的抗脂解作用介导。
Abstract:
This study is conducted to investigate the effect of curcumin on the progression of insulin resistance and type 2 diabetes mellitus (T2DM) and the mechanisms underlying this effect. Insulin resistance and T2DM were induced in male Sprague Dawley rats by high fat diet (HFD) feeding for 60 days. Prophylactic oral administrations of curcumin (80 mg/kg), rosiglitazone (1 mg/kg), their combination or vehicle (in control groups) started along with HFD feeding in different groups. After 60 days of treatments, blood was collected for detecting changes of FBG, FINS, TC, HDL, TG, LDL and FFA. Insulin resistance (HOMA2-IR) was calculated using a computer model of the Homeostasis Model Assessment (HOMA2). Plasma level of TNF-α was determined by radioimmunoassay. Curcumin showed an anti-hyperglycemic effect and improved insulin sensitivity, and this action may be attributed at least in part to its anti-inflammatory properties as evident by attenuating TNF-α levels in HFD fed rats, and its anti-lipolytic effect as evident by attenuating plasma free fatty acids.

相似文献/References:

[1]陈洁.姜黄素对胰岛素抵抗大鼠脂肪细胞因子的影响[J].武汉职业技术学院学报,2014,(05):96.
　CHEN Jie.Influences of Curcumin for Insulin Resistance Factors of Fat Cells of Rats[J].Journal of Wuhan Polytechnic,2014,(01):96.

备注/Memo

备注/Memo:
收稿日期：2015-12-16 基金项目：湖北省教育厅科学研究计划指导性项目“姜黄素对2型糖尿病大鼠脂肪细胞内分泌功能的干预及机制研究”（项目编号：B2015423）。 作者简介：陈洁（1980-），女，湖北武汉人，硕士，武汉职业技术学院生物工程学院讲师，研究方向：生化药理、分子生物学。
更新日期/Last Update: 2016-02-28